Avoiding Surgery in Locally Advanced Rectal Cancer

Someone Somewhere

Complete response after chemoradiation may identify low-risk subgroup.

 Three-fourths of patients with locally advanced rectal cancer avoided surgery following complete clinical response to chemoradiation therapy, data from a retrospective analysis showed.

After a median follow-up of 3.3 years, 54 of 73 patients had durable remissions after achieving complete responses with chemotherapy and radiation. The 73 patients had a 4-year overall survival of 91%, which did not differ significantly from the 4-year survival of 95% in a historical comparison group that had surgery upfront.

The findings build on previous observations from studies originating in Brazil and the Netherlands, said Philip Paty, MD, of Memorial Sloan Kettering Cancer Center in New York City, at a press briefing held in advance of the Gastrointestinal Cancers Symposium here later this week.

“Nonoperative management for patients with clinical complete response after neoadjuvant therapy led to a 74% durable clinical response rate, local tumor regrowth…

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